Epileptogenic networks in extra temporal lobe epilepsy

Abstract Extra temporal lobe epilepsy (eTLE) may involve heterogenous widespread cerebral networks. We investigated the structural network of an eTLE cohort, at postulated epileptogenic zone later surgically removed, as a node; resection (RZ). hypothesised patients with abnormal connection to/from RZ, to have proportionally increased abnormalities based on topological proximity in addition poorer post-operative seizure outcome. Structural and diffusion MRI were collected for 22 pre- post-surgery, 29 healthy controls. The connectivity RZ prior surgery, measured via generalised fractional anisotropy (gFA), was compared Abnormal connections identified those substantially reduced gFA (z < −1.96). For one or more closer distance had higher proportion abnormalities. minority seizure-free (3/11) connections, whilst most non-seizure free (8/11) RZ. Our data suggest proportional associated chance freedom post-surgery.